[Research Progress of Non-coding RNA and Endometrial Receptivity]

Area of Science:

• Reproductive biology
• Genetics
• Molecular biology

Background:

• Endometrial receptivity is critical for successful pregnancy, especially in assisted reproductive technologies like in vitro fertilization (IVF).
• Impaired endometrial receptivity is a leading cause of IVF failure and infertility, leading to significant patient distress and economic burden.
• Non-coding RNAs (ncRNAs) are emerging as key regulators in various biological processes, including reproduction.

Purpose of the Study:

• To review the current understanding of the role of non-coding RNAs in regulating endometrial receptivity.
• To highlight the potential of ncRNAs as diagnostic markers and therapeutic targets for improving endometrial receptivity and IVF outcomes.

Main Methods:

• Literature review of studies investigating non-coding RNAs and their association with endometrial receptivity.
• Analysis of findings related to different classes of non-coding RNAs, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs).

Main Results:

• Non-coding RNAs, including miRNAs and lncRNAs, are differentially expressed in the receptive endometrium.
• These ncRNAs regulate key pathways involved in embryo implantation, such as cell adhesion, invasion, and immune response.
• Dysregulation of ncRNAs is linked to diminished endometrial receptivity and recurrent implantation failure.

Conclusions:

• Non-coding RNAs are integral to the complex process of establishing endometrial receptivity.
• Targeting specific non-coding RNAs presents a promising avenue for developing novel strategies to enhance fertility treatments and improve pregnancy success rates in infertile patients.