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Arterial hypertension associated with hyperuricemia: features of heart damage

Olha M Chernatska1, Liudmyla N Prystupa1, Hanna A Fadieieva1

  • 1Internal Medicine Department, Medical Institute, Sumy State University, Sumy, Ukraine.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|May 10, 2020
PubMed

Insights

Hyperuricemia significantly increases left ventricular mass index in patients with arterial hypertension, indicating its role in developing left ventricular hypertrophy. This finding highlights the importance of managing uric acid levels in hypertensive individuals.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Disorders

Background:

  • Arterial hypertension is a major risk factor for cardiovascular diseases.
  • Hyperuricemia, elevated uric acid levels, is increasingly recognized as a potential contributor to cardiovascular complications.
  • The relationship between hyperuricemia and cardiac remodeling in hypertensive patients requires further elucidation.

Purpose of the Study:

  • To analyze the influence of hyperuricemia on cardiac features in patients with arterial hypertension.
  • To investigate the association between serum uric acid levels and left ventricular hypertrophy (LVH).

Main Methods:

  • A study involving 75 patients with arterial hypertension, divided into groups based on uric acid levels.
  • Inclusion of 30 healthy individuals as a control group.
  • Assessment of left ventricular mass index (LVMI) to confirm left ventricular hypertrophy, utilizing clinical, anthropometric, biochemical, and instrumental methods.

Main Results:

  • Patients with arterial hypertension and hyperuricemia exhibited a significantly higher left ventricular mass index (109.7 ± 3.21 g/m²) compared to those with arterial hypertension alone (97.6 ± 5.35 g/m²).
  • Left ventricular mass index showed a positive correlation with serum uric acid levels (r = 0.31; p = 0.04) in patients with arterial hypertension and hyperuricemia.
  • The findings suggest a proportional increase in LVH with rising uric acid levels.

Conclusions:

  • Hyperuricemia plays a significant role in the development of left ventricular hypertrophy in patients with arterial hypertension.
  • Elevated left ventricular mass index, correlated with uric acid levels, confirms the impact of hyperuricemia on cardiac structure.
  • Management of hyperuricemia may be crucial in preventing or mitigating cardiac remodeling in hypertensive individuals.
Abstract

Keywords:
hyperuricemialeft ventricular mass indexarterial hypertension

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