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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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THE CHRONIC KIDNEY DISEASE RISK ANALYSIS IN PATIENTS WITH ARTERIAL HYPERTENSION AND COEXISTENT HYPERURICEMIA

Olha M Chernatska1, Liudmyla N Prystupa1, Hanna A Fadieieva1

  • 1INTERNAL MEDICINE DEPARTMENT WITH RESPIRATORY MEDICINE CENTER, SUMY STATE UNIVERSITY MEDICAL INSTITUTE, SUMY, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|June 5, 2021
PubMed

Insights

Patients with arterial hypertension and hyperuricemia face increased chronic kidney disease risk. Elevated uric acid levels are linked to worsening kidney disease in these individuals.

Area of Science:

  • Nephrology
  • Cardiology
  • Metabolic Diseases

Background:

  • Arterial hypertension is a major risk factor for chronic kidney disease (CKD).
  • Hyperuricemia, elevated uric acid levels, is increasingly recognized as a contributor to kidney damage.
  • The combined effect of hypertension and hyperuricemia on CKD risk requires further investigation.

Purpose of the Study:

  • To analyze the risk of developing chronic kidney disease (CKD) in patients with coexisting arterial hypertension and hyperuricemia.
  • To compare CKD risk between patients with hypertension and hyperuricemia versus those with hypertension alone.
  • To assess the association between uric acid levels and CKD progression markers.

Main Methods:

  • Observational study involving three groups: hypertension with hyperuricemia (n=40), hypertension alone (n=35), and healthy controls (n=30).
  • Assessment of albuminuria categories (A1-A3) and glomerular filtration rate (GFR) stages (G1-G5) in all participants.
  • Utilized clinical, anthropometric, biochemical, and immunoassay methods, with statistical analysis using SPSS and Graph Pad.

Main Results:

  • Patients with hypertension and hyperuricemia exhibited a higher prevalence of advanced albuminuria and reduced GFR categories compared to the hypertension-only group.
  • A significant percentage of patients in the hypertension with hyperuricemia group (10%) presented with high or very high CKD risk.
  • The hypertension-only group showed a higher proportion of low CKD risk (5.7%) compared to the comorbid group.

Conclusions:

  • Coexistent arterial hypertension and hyperuricemia significantly increase the risk of chronic kidney disease.
  • Elevated uric acid levels are associated with an increased risk and progression of CKD in hypertensive patients.
  • This study highlights the importance of managing hyperuricemia in hypertensive individuals to mitigate CKD development.
Abstract

Keywords:
arterial hypertensionchronic kidney disease riskhyperuricemia

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