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Related Experiment Videos

Disorders of phagocytic function: ultrastructural aspects.

S D Douglas

    Progress in Clinical and Biological Research
    |January 1, 1977
    PubMed
    Summary
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    Electron microscopy reveals structural changes in granulocytes linked to genetic and acquired disorders. While some conditions show giant lysosomes or Döhle bodies, others like chronic granulomatous disease lack visible abnormalities, impacting phagocytic function.

    Area of Science:

    • Hematology
    • Cell Biology
    • Pathology

    Background:

    • Granulocytes are crucial immune cells whose function can be impaired by genetic and acquired disorders.
    • Electron microscopy provides detailed insights into cellular ultrastructure, aiding in the diagnosis and understanding of hematological conditions.

    Purpose of the Study:

    • To review electron microscopic findings in various granulocyte disorders.
    • To correlate observed morphological changes with functional deficits in granulocytes.

    Main Methods:

    • Review of existing literature on electron microscopy of granulocytes in different disease states.
    • Correlation of ultrastructural abnormalities with clinical and functional data.

    Main Results:

    Related Experiment Videos

  • Chédiak-Higashi syndrome exhibits giant lysosomes.
  • Chronic granulomatous disease shows no qualitative morphological abnormalities despite impaired phagocytosis.
  • Döhle bodies and cytoplasmic vacuolization are observed in granulocytes during chronic infection and kwashiorkor.

    • Conclusions:

    • Electron microscopy is valuable for identifying specific ultrastructural changes in granulocyte disorders.
    • Further understanding of granulocyte function requires integrating advanced cytochemical methods with electron microscopy and in vitro techniques.