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[The effect of acetoacetate on 3-hydroxybutyrate oxidation by rat liver mitochondria]
Ukrainskii Biokhimicheskii Zhurnal (1978)
|November 1, 1988
Abstract:
Effect of acetoacetate on 3-hydroxybutyrate oxidation by rat liver mitochondria is described. State 3 respiration is inhibited by acetoacetate, while state 4 respiration is not inhibited, though cytochrome c reduction was decreased. Acetoacetate is also non-competitive inhibitor of 3-hydroxybutyrateoxidase and 3-hydroxybutyrate dehydrogenase activity in frozen-thawed mitochondria. The results are discussed in terms of the thermodynamic hypothesis and control strength method.