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Pesticides-induced energy metabolic disorders
Bingnan He1, Yinhua Ni1, Yuanxiang Jin1
1College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China.
The Science of the Total Environment
|May 11, 2020
Summary
Pesticides disrupt energy metabolism, leading to metabolic disorders like diabetes and obesity. This review summarizes how pesticide exposure impacts energy balance and related diseases.
Area of Science:
- Environmental Science
- Toxicology
- Metabolic Disorders
Background:
- Pesticides are environmental contaminants found in food chains.
- Pesticide exposure poses health risks, including metabolic disturbances.
- Metabolic disorders represent a significant societal burden.
Purpose of the Study:
- To review existing research on pesticide-induced metabolic disorders.
- To explore the mechanisms by which pesticides affect energy metabolism.
- To identify potential therapeutic strategies for pesticide-related diseases.
Main Methods:
- Literature review of studies on pesticides and metabolic health.
- Analysis of evidence linking pesticide exposure to disrupted energy homeostasis.
- Synthesis of findings on pesticide effects on key metabolic tissues and organs.
Main Results:
- Pesticides disrupt intestinal energy absorption and tissue energy storage (liver, adipose, muscle).
- Pancreatic and immune cell energy regulation is affected by pesticide exposure.
- Pesticide-induced metabolic disruption leads to abnormal blood glucose/lipids, causing diseases like obesity and diabetes.
Conclusions:
- Pesticides are a significant environmental factor contributing to metabolic disorders.
- Understanding these mechanisms is crucial for developing targeted treatments.
- Further research may uncover strategies to mitigate pesticide-induced metabolic diseases.
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