Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-time cancer monitoring via leukocyte adhesion in a biomimetic microfluidic assay.

Biosensors & bioelectronics·2025
Same author

A novel framework for forward osmosis in zero- and low-flow conditions: Applicability and fundamental differences from reverse osmosis.

Water research·2025
Same author

Synovium-on-a-Chip Reveals Fibroblast-Macrophage Crosstalk Underpinning Joint Homeostasis and Evaluation of Gout Therapies.

Advanced healthcare materials·2025
Same author

Need of Treatment Modification During Entecavir Therapy in Patients with Chronic Hepatitis B: Long-Term Follow-Up Results for 120 Months.

Microorganisms·2025
Same author

Fast and accurate multi-bacterial identification using cleavable and FRET-based peptide nucleic acid probes.

Biosensors & bioelectronics·2024
Same author

Short and long term effect of anti-reflux mucosectomy with cap-assisted endoscopic mucosal resection for refractory gastroesophageal disease.

Surgical endoscopy·2024

Related Experiment Video

Updated: Dec 21, 2025

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

8.3K

Primary Gliosarcoma with Extracranial Metastasis.

Min Gyu Choi1, Jeong Ho Lee2, Min Seok Lee1

  • 1Department of Neurosurgery, Daegu Fatima Hospital, Daegu, Korea.

Brain Tumor Research and Treatment
|May 12, 2020
PubMed
Summary

This case study highlights a rare instance of gliosarcoma, a brain tumor with both glial and sarcomatous elements. The patient experienced widespread metastasis, leading to a fatal outcome despite initial treatment.

Keywords:
Brain tumorGlioblastomaGliosarcoma

More Related Videos

Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

3.4K
Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
05:45

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

2.7K

Related Experiment Videos

Last Updated: Dec 21, 2025

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation
09:43

Primary Orthotopic Glioma Xenografts Recapitulate Infiltrative Growth and Isocitrate Dehydrogenase I Mutation

Published on: January 14, 2014

8.3K
Translational Orthotopic Models of Glioblastoma Multiforme
07:37

Translational Orthotopic Models of Glioblastoma Multiforme

Published on: February 17, 2023

3.4K
Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma
05:45

Author Spotlight: Enhanced Generation of Patient-Derived 3D Organoids for Glioblastoma and Glioma

Published on: January 19, 2024

2.7K

Area of Science:

  • Neuro-oncology
  • Pathology

Background:

  • Glioblastoma multiforme is an aggressive primary brain tumor.
  • Gliosarcoma is a rare variant with glial and sarcomatous components, often presenting diagnostic challenges.

Observation:

  • A 69-year-old male initially diagnosed with glioblastoma multiforme developed widespread metastatic disease.
  • Metastasis included lesions in the liver, lungs, pleura, lymph nodes, bones, and muscles.
  • Pathological review confirmed a sarcomatous component, revising the diagnosis to metastatic gliosarcoma.

Findings:

  • The patient presented with neurological deficits, underwent resection and adjuvant therapy for presumed glioblastoma.
  • Subsequent development of epigastric pain led to the discovery of extensive metastatic disease.
  • Histopathological analysis of both the primary brain tumor and liver biopsy confirmed the diagnosis of gliosarcoma.

Implications:

  • This case underscores the importance of thorough pathological review, especially when clinical presentation or disease progression is atypical.
  • Gliosarcoma, though rare, can exhibit aggressive behavior with widespread metastasis.
  • The diagnostic and therapeutic challenges associated with gliosarcoma warrant further investigation.