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Leptin-Mediated Changes in the Human Metabolome.

Katherine Lawler1, Isabel Huang-Doran1, Takuhiro Sonoyama1

  • 1University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

The Journal of Clinical Endocrinology and Metabolism
|May 12, 2020
PubMed
Summary

Leptin replacement therapy in severe obesity due to leptin deficiency improved fat metabolism. Some metabolic changes were linked to reduced calorie intake, but others, like effects on amino acids and steroids, were independent and need more study.

Keywords:
bile acidsleptinlipidsmetabolomicsobesity

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