Related Experiment Video
Updated: Dec 21, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Association between interleukin-8 -251A/T polymorphism and the risk of tuberculosis: A meta-analysis
Qin Hu1, Haibo Hua1, Lihong Zhou1
1Department of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou, China.
Objective:
The relationship between interleukin-8 (IL8) -251A/T polymorphism and tuberculosis (TB) risk remains controversial. Therefore, the present meta-analysis was performed by retrieving relevant studies from the available literature.
Methods:
We comprehensively searched three databases to identify eligible literature on the relationship of IL8 -251A/T polymorphism with TB risk, calculated pooled odds ratios (OR) with 95% confidence intervals (CI), and subsequent evaluated the heterogeneity and publication bias.
Results:
We found that IL8 -251A/T polymorphism increased TB risk (AA vs. TT: OR = 2.86, 95%CI: 1.46-5.60; AT vs. TT: OR = 1.64, 95%CI: 1.15-2.34; dominant model: OR = 1.88, 95%CI: 1.24-2.86; recessive model: OR = 1.77, 95%CI: 1.17-2.69). Subgroup analyses based on race revealed that the IL8 -251A/T polymorphism might be associated with the risk of TB in African but not Asian individuals.
Conclusion:
The IL8 -251A/T polymorphism might be related to the risk of TB. Nevertheless, large-scale studies should be performed to confirm the role of IL8 -251A/T polymorphism on TB risk.
Related Concept Videos
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis III
The first classification is based on the development of the disease, and it includes the following categories:
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Single Nucleotide Polymorphisms-SNPs
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...

