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Mean platelet volume levels in children with sleep-disordered breathing: a meta-analysis

Wen-Dien Chang1, Chih-Hao Tseng2, Yung-An Tsou3,4

  • 1Department of Sport Performance, National Taiwan University of Sport, Taichung, Taiwan.

BMC Pediatrics
|May 13, 2020
PubMed

Insights

Pediatric sleep-disordered breathing (SDB) is linked to higher mean platelet volume (MPV), an inflammatory marker. Surgery, particularly adenotonsillectomy, can significantly reduce MPV levels in these children.

Area of Science:

  • Pediatric Pulmonology
  • Hematology
  • Sleep Medicine

Background:

  • Pediatric sleep-disordered breathing (SDB) is associated with snoring and hypopnea.
  • Mean platelet volume (MPV) serves as an inflammatory marker, with elevated levels potentially linked to failure to thrive and increased respiratory infections in children.

Purpose of the Study:

  • To systematically review and meta-analyze studies investigating MPV values in pediatric SDB.
  • To compare MPV changes in pediatric SDB patients before and after surgical intervention.

Main Methods:

  • A systematic review of PubMed, EMBASE, and Cochrane Library databases was conducted.
  • Meta-analysis and subgroup analysis were employed to compare MPV levels in pediatric SDB and assess post-surgical changes.

Main Results:

  • Six studies (963 subjects) revealed significantly higher MPV in pediatric SDB patients compared to controls (SMD=0.51, P<0.05).
  • A significant MPV decrease was observed post-surgery in pediatric SDB patients (SMD=-0.36, P<0.05).
  • Adenotonsillectomy demonstrated a statistically significant reduction in MPV (SMD=-0.72, P<0.05).

Conclusions:

  • Elevated MPV in pediatric SDB indicates increased platelet activity.
  • Surgical interventions, especially adenotonsillectomy, can effectively reduce MPV levels in pediatric SDB patients.
Abstract

Keywords:
Mean platelet volumePediatric sleep disordered breathingSnoring

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