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Red cell size heterogeneity during ontogeny.

B P Alter1, J D Goldberg, R L Berkowitz

  • 1Polly Annenberg Levee Hematology Center, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029.

The American Journal of Pediatric Hematology/Oncology
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Red blood cell size variation, measured by red cell distribution width (RDW), increases significantly from fetal development to birth. This suggests non-continuous erythrocyte production during the perinatal period.

Area of Science:

  • Hematology
  • Developmental Biology
  • Perinatal Medicine

Background:

  • Erythrocyte parameters change throughout human development.
  • Understanding red blood cell (RBC) ontogeny is crucial for perinatal health assessments.

Purpose of the Study:

  • To investigate the changes in erythrocyte parameters during human development, from fetus to adulthood.
  • To characterize the pattern of red blood cell size variation during the perinatal period.

Main Methods:

  • Analysis of red cell parameters including mean cell volume (MCV) and hemoglobin F (HbF).
  • Quantification of red cell size variation using the coefficient of variation (%CV) and red cell distribution width (RDW).
  • Comparison of these parameters across different developmental stages: fetal, newborn, child, and adult.

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Main Results:

  • Mean cell volume (MCV) and Hemoglobin F (HbF) levels decreased with gestational age, as expected.
  • The coefficient of variation of red cell size (%CV), or red cell distribution width (RDW), significantly increased from fetuses (18%) to newborns (21%).
  • Adults exhibited a %CV of 15 (RDW of 13), indicating a return to a more uniform cell size post-natally.

Conclusions:

  • Erythropoiesis at birth is a non-steady-state condition characterized by significant anisocytosis (variation in RBC size).
  • The observed increase in RDW suggests that new erythrocyte production during the perinatal period may occur through discrete, possibly clonal, events rather than continuous size evolution.
  • These findings highlight dynamic changes in red blood cell production during late gestation and immediately after birth.