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Updated: Dec 21, 2025

High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging
Published on: November 10, 2015
Normal and pathological imaging of the hippocampus in geriatric patients
Damien Combes1, Jean-Yves Tanguy1, Cédric Annweiler2
1Département de radiologie, CHU d'Angers, France.
Abstract:
The hippocampus is a small internal temporal cerebral structure which plays a primordial role in memory mechanisms. Magnetic resonance imaging (MRI) is the preferred method for analysing this structure. In older adults, dementia is the major cause of hippocampal anomalies, particularly atrophic anomalies, however, differential diagnoses involving other specific pathologies should also be recognised in this population. Most acute or recent hippocampal damage is detected based on MRI signal abnormalities. The aim of this article is to provide an iconographic review of normal and pathological hippocampal imaging in older adults with degenerative, infectious, vascular, inflammatory, tumoural, toxic, and metabolic disorders.
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