Related Experiment Video
Updated: Dec 21, 2025
08:25
Evaluating the Function of the Foot Core System in the Elderly
Published on: March 11, 2022
3.1K
Functional Capacity and Inflammatory Mediators in Elderly Residents of Counties with Different Human Development
Lygia P Lustosa1, Daniele R Xavier1, Giane A Ribeiro-Samora1
1Post-Graduate Program in Rehabilitation Science, Physical Therapy Department, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Journal of Aging Research
|May 14, 2020
Summary
Older women in high Human Development Index (HDI) counties showed lower functional capacity and reduced soluble tumor necrosis factor receptor 1 (sTNFR-1) levels. Regional differences in education, income, and disease impact aging and inflammation.
Area of Science:
- Gerontology
- Immunology
- Public Health
Background:
- Socioeconomic status and education impact elderly functional health.
- Chronic inflammation, indicated by elevated cytokines like IL-6 and sTNFR-1, is common in aging and may impair function.
Purpose of the Study:
- To compare plasma inflammatory mediator levels and functional capacity in older women across Brazilian counties with varying Human Development Index (HDI).
Main Methods:
- Cross-sectional study of 154 women aged ≥65 years.
- Measured plasma IL-6 and sTNFR-1 via ELISA.
- Assessed functional capacity using the Short Physical Performance Battery (SPPB) test.
Main Results:
- Women in high HDI counties exhibited lower functional capacity (p < 0.001).
- The highest HDI county group had lower sTNFR-1 levels (p < 0.05), but IL-6 levels did not differ significantly.
- Lower HDI counties showed higher self-reported diseases and income; highest HDI county had higher education levels.
Conclusions:
- Significant regional differences exist in functional capacity and sTNFR-1 levels among older women.
- Education, income, and self-reported diseases vary regionally, influencing aging, inflammation, and functional capacity.
Related Concept Videos
01:15Drug Dosing: Geriatric Patients
161
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
161
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
135
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
135
01:19The Effect of Aging on Tissues
3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
01:21Dimensions of Health and Illness
9.5K
The factors influencing the health-illness continuum can be internal or external and may or may not be under conscious control. They are related to the following eight human dimensions, and each dimension is interrelated to one other.
9.5K
01:18Factors Affecting Illness
4.9K
When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
For instance, risk factors are connected to illness,...
4.9K
01:00Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
127
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
127