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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Euphopanes A-C, three new diterpenoids from Euphorbia pekinensis
Xue-Long Yan1, Jia-Luo Huang1, Ya-Qi Tang1
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
Abstract:
Three new diterpenoids, euphopanes A-C (1-3), including one ent-isopimarane (1), one ent-abietane (2) and one cembrane (3), along with five known compounds (4-8) were isolated from the roots of Euphorbia pekinensis. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configurations of compounds 1-3 were determined by ECD calculations. All the isolates were screened for the cytotoxicity against three cancer cell lines (C4-2B, C42B/ENZR, and MDA-MB-231), and compounds 1, 2, and 4 showed significant cytotoxicity against human prostate cancer cells C4-2B with IC50 values of 14.3, 16.9, and 15.3 μM, respectively.
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