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[Bone marrow monosomy 7 in children].

B Nelken1, J L Lai, T Facon

  • 1L'Unité d'Hématologie Oncologique, Hôpital Calmette, Lille.

Archives Francaises De Pediatrie
|December 1, 1988
PubMed
Summary
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Monosomy 7, a chromosome deletion, is linked to poor prognosis in myeloproliferative disorders. Early detection in patients with monocytosis is crucial for timely intervention and improved outcomes.

Area of Science:

  • Genetics
  • Hematology
  • Oncology

Context:

  • Presents three new cases of monosomy 7 in children.
  • Two cases exhibited preleukemic states before overt leukemia.
  • One case presented with subacute myelomonocytic leukemia (juvenile chronic myelogenous leukemia).

Purpose:

  • To describe new cases of monosomy 7.
  • To highlight the association between monosomy 7 and preleukemic states.
  • To emphasize the poor prognosis associated with monosomy 7.

Summary:

  • Monosomy 7 is a chromosome deletion associated with myeloproliferative disorders.
  • Preleukemic states, including myelodysplastic syndrome and monocytosis, were observed.
  • Leukemia in two cases was chemoresistant, and one patient died from cachexia.

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Impact:

  • Underlines the poor prognosis of monosomy 7.
  • Recommends searching for monosomy 7 in myeloproliferative syndromes with monocytosis.
  • Suggests implications for early diagnosis and treatment strategies.