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Updated: Aug 18, 2026

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
Published on: March 11, 2017
Hypolipidemic drug clofibrate promotes hepatic tumor
1Dept. of Microbiology, Cancer Institute, Madras, India.
Abstract:
In diethylnitrosamine-initiated rats, administration of clofibrate for 32 weeks induced neoplastic lesions and hepatocellular carcinoma. In contrast to conventional carcinogens, clofibrate effected a marked decrease in the activity of gamma-glutamyltranspeptidase. Ornithine was selectively channeled into polyamine synthesis with concomitant repression of the urea cycle and the transamination pathway. These histological and biochemical studies suggest that clofibrate acts as a promoting agent in hepatocarcinogenesis.
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