Related Experiment Video

Updated: Dec 21, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.7K

Prognostic Value of Cardiovascular Biomarkers in COVID-19: A Review

Maryam Aboughdir1,2, Thomas Kirwin1,3, Ashiq Abdul Khader1

  • 1Department of Medicine, Imperial College London, London W12 0NN, UK.

Viruses
|May 15, 2020
PubMed

Insights

This review identifies cardiovascular prognostic factors for COVID-19 patients, highlighting biomarkers for cardiac injury and coagulation to predict outcomes and optimize care for those with cardiovascular disease.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Biomarkers

Background:

  • COVID-19, caused by SARS-CoV-2, emerged in late 2019 with significant global impact.
  • Hospitalized COVID-19 patients frequently have pre-existing cardiovascular disease (CVD).
  • COVID-19 can worsen cardiovascular risk factors, existing CVD, and lead to complications.

Purpose of the Study:

  • To identify cardiovascular prognostic factors linked to morbidity and mortality in COVID-19.
  • To explore the role of cardiac injury and coagulation biomarkers in predicting COVID-19 outcomes.
  • To guide the use of laboratory testing for cardiovascular biomarkers to improve patient management.

Main Methods:

  • Literature review of studies on COVID-19 and cardiovascular outcomes.
  • Analysis of preliminary findings associating biomarkers with prognosis.
  • Synthesis of evidence on cardiovascular risk factors and complications in COVID-19 patients.

Main Results:

  • Preliminary data suggest biomarkers of acute cardiac injury and coagulation are associated with worse prognosis in COVID-19.
  • Patients with pre-existing CVD or risk factors appear to be at higher risk for adverse outcomes.
  • The review consolidates evidence on key cardiovascular prognostic indicators.

Conclusions:

  • Identifying patients at increased risk of adverse outcomes is crucial during the COVID-19 pandemic.
  • Cardiovascular prognostic factors and biomarkers are vital for managing COVID-19 patients, especially those with comorbidities.
  • Incorporating biomarker testing can optimize patient outcomes and inform clinical decision-making.

Keywords:
COVID-19SARS-CoV-2cardiovascular diseasecoronavirus

More Related Videos

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies05:30

Author Spotlight: Advancing the Analysis of Plasma Extracellular Vesicle Proteome for Cardiovascular Biomarker Studies

Published on: January 31, 2025

950
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

7.9K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
437
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
689
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
143
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
779
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
289
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
289