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Updated: Dec 21, 2025

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
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Multi-channel surface plasmon resonance biosensor using prism-based wavelength interrogation.

Jieyao Li, Dandan Han, Junyi Zeng

    Optics Express
    |May 15, 2020
    PubMed
    Summary
    This summary is machine-generated.

    This study presents a portable, multi-channel surface plasmon resonance (SPR) biosensor for efficient detection. The device utilizes a prism-based wavelength interrogation and a cost-effective spectrometer for high-throughput analysis.

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    Area of Science:

    • Biosensing
    • Optical Spectroscopy
    • Nanotechnology

    Background:

    • Surface Plasmon Resonance (SPR) biosensors offer label-free detection capabilities.
    • Miniaturization and cost-effectiveness are crucial for widespread adoption of SPR technology.
    • Multi-channel analysis enhances throughput and efficiency in biosensing applications.

    Purpose of the Study:

    • To develop a portable, multi-channel SPR biosensor device.
    • To utilize prism-based wavelength interrogation with LEDs as a light source.
    • To achieve simultaneous spectral image acquisition for improved detection.

    Main Methods:

    • A portable SPR biosensor was designed using prism-based wavelength interrogation.
    • LEDs were employed as a stable light source, coupled with a collimated unit.
    • A compact spectrometer comprising lenses and a prism collected reflected light.
    • A multi-channel microfluidic chip served as the sensing component.

    Main Results:

    • The device achieved a linear detection range of 4.32 × 10-2 refractive index units (RIU).
    • The limit of detection was determined to be 6.38 × 10-5 RIU.
    • Simultaneous spectral image acquisition from multiple tests was demonstrated.

    Conclusions:

    • The developed portable SPR biosensor is cost-effective and enables high-throughput analysis.
    • The system demonstrates reliable performance for detecting analytes like immunoglobulin G (IgG).
    • This miniaturized SPR device holds potential for various point-of-care diagnostic applications.