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Relocating a pediatric hospital: Does antimicrobial resistance change?
Annika Schönfeld1, Rudolf Ascherl2, Stefanie Petzold-Quinque1
1Hospital for Children and Adolescents, University Hospital Leipzig, Liebigstraße 20a, 04103, Leipzig, Germany.
BMC Research Notes
|May 15, 2020
Summary
Hospital relocation impacted antimicrobial resistance patterns. Minimum inhibitory concentrations (MICs) revealed shifts in drug susceptibility for common pathogens, highlighting the need for ongoing surveillance post-transfer.
Area of Science:
- Infectious Diseases
- Clinical Microbiology
- Hospital Epidemiology
Background:
- Hospital relocations can influence the epidemiology of antimicrobial resistance.
- Understanding these shifts is crucial for effective infection control and treatment strategies.
Purpose of the Study:
- To analyze changes in antimicrobial drug resistance patterns following a pediatric university hospital's relocation.
- To evaluate shifts in minimum inhibitory concentrations (MICs) for key pathogens.
Main Methods:
- Retrospective analysis of microbiological data, focusing on MICs.
- Comparison of data from before and after the hospital move.
- Inclusion of isolates from blood, urine, and bronchial secretions.
Main Results:
- Increased detection rates for specific bacteria including *Acinetobacter baumannii*, *Enterococcus faecalis*, *Klebsiella* spp., and *Proteus mirabilis*.
- Significant changes in MICs for *Enterococcus faecium* across multiple antimicrobials.
- Observed increases in MICs for imipenem and aminopenicillins, and decreases for gentamicin and trimethoprim/sulfamethoxazole post-relocation.
Conclusions:
- Hospital relocation is associated with detectable alterations in antimicrobial resistance profiles.
- MIC analysis provides a granular view of resistance changes, surpassing categorical reporting.
- Continuous monitoring of antimicrobial susceptibility is essential after significant facility changes.
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