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Updated: Dec 21, 2025

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

Published on: March 15, 2019

Lipotransfer provides effective soft tissue replacement for acquired partial lipodystrophy.

Faith Hyun Kyung Jeon¹, Michelle Griffin^2,3, Carole Frosdick³

¹Division of Surgery & Interventional Science, University College London, London, UK h.jeon@outlook.com.

BMJ Case Reports

|May 15, 2020

Summary

Acquired partial lipodystrophy (APL), or Barraquer-Simons syndrome, is a rare condition causing fat loss in specific body areas. Autologous fat transfer offers a safe and effective surgical solution for reconstruction in APL patients.

Keywords:

breast surgery plastic and reconstructive surgery

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Last Updated: Dec 21, 2025

Mechanical Micronization of Lipoaspirates for Regenerative Therapy

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Assessment of Viability of Human Fat Injection into Nude Mice with Micro-Computed Tomography

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Human Adipose Tissue Micro-fragmentation for Cell Phenotyping and Secretome Characterization

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Area of Science:

Plastic Surgery
Dermatology
Endocrinology

Background:

Acquired partial lipodystrophy (APL), also known as Barraquer-Simons syndrome, is a rare disorder.
APL is characterized by progressive lipoatrophy affecting the face, neck, upper body, and abdomen, while sparing the lower extremities.

Observation:

Patients with APL often experience significant psychosocial distress due to their physical appearance.
Misdiagnosis and delayed management can exacerbate the condition and its impact.

Findings:

Treatment focuses on surgical correction of soft tissue defects.
Autologous fat transfer is a minimally invasive and safe reconstructive procedure for soft tissue defects.

Implications:

Autologous fat transfer is an effective treatment for APL, improving both physical appearance and quality of life.
Early recognition and appropriate management, including surgical reconstruction, are crucial for patients with APL.