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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

240
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
240
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

222
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
222

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Related Experiment Video

Updated: Dec 21, 2025

Innovative Strategies for Organ Preservation in Heart Transplantation: Uniform Cooling Preservation and Ex-situ Normothermic Perfusion
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Donor Age, Cold Ischemia Time, and Delayed Graft Function.

Ilkka Helanterä1, Hassan N Ibrahim2, Marko Lempinen1

  • 1Abdominal Center, Department of Transplantation and Liver Surgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

Clinical Journal of the American Society of Nephrology : CJASN
|May 15, 2020
PubMed
Summary
This summary is machine-generated.

This study found that while longer cold ischemia time increases the risk of delayed graft function (DGF) in kidney transplants, older donor age did not significantly worsen this risk. The impact of cold ischemia time was not amplified in older or marginal donors.

Keywords:
Body Mass IndexCause of DeathCohort StudiesCold IschemiaEpidemiology and outcomesKidney DiseasesRegistriesRetrospective StudiesTissue DonorsTransplant Recipientscadaver organ transplantationcreatininedelayed graft functiondiabetes mellitushypertensionkidney transplantationrenal dialysisrisk factorstransplant outcomes

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Area of Science:

  • Nephrology
  • Transplantation immunology
  • Public health

Background:

  • Donor age is a significant risk factor for delayed graft function (DGF) after kidney transplantation.
  • Previous research indicated that cold ischemia time exacerbates the negative impact of older donor age on graft outcomes.
  • This study aimed to re-evaluate these associations in a contemporary kidney transplant cohort.

Purpose of the Study:

  • To investigate the independent and interactive effects of donor age and cold ischemia time on the risk of DGF.
  • To analyze these associations within a large cohort of deceased donor kidney transplants performed in the current era.

Main Methods:

  • Retrospective analysis of the Scientific Registry of Transplant Recipients (SRTR) database.
  • Inclusion of deceased donor kidney transplants in the US from 2010 to September 2018 (n=90,810).
  • Multivariable regression models adjusted for recipient and donor characteristics were used to assess associations.

Main Results:

  • Both cold ischemia time and donor age were independently associated with DGF risk.
  • No statistically significant increase in DGF risk was observed for donor age categories between 50-64 years compared to those ≥65 years.
  • The detrimental effect of cold ischemia time on DGF risk was not amplified in older donors, including donation after circulatory death donors.

Conclusions:

  • The study did not demonstrate a significant association between donor age and DGF in the current era.
  • Longer cold ischemia time's association with DGF risk was not magnified in older or marginal donors.
  • Kidney donor profile index did not show a practically meaningful increase in cold-ischemia susceptibility for high-risk kidneys.