Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cycloalkanes02:28

Cycloalkanes

15.1K
Cycloalkanes are saturated cyclic hydrocarbons with carbon atoms arranged in the form of rings. They have two fewer hydrogen atoms than the corresponding acyclic alkane; therefore, their general formula is CnH2n. The structural formulas of cycloalkanes are simplified using the line-angle representation. The regular polygons are used to represent the cycloalkane rings, with each side representing a carbon-carbon bond.
The IUPAC nomenclature of cycloalkanes follows similar rules that apply to...
15.1K
Alkylation of β-Diester Enolates: Malonic Ester Synthesis01:14

Alkylation of β-Diester Enolates: Malonic Ester Synthesis

4.0K
Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
4.0K
Carboxylic Acid Derivatives: Overview01:15

Carboxylic Acid Derivatives: Overview

5.0K
Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:
5.0K
IUPAC Nomenclature of Carboxylic Acids01:16

IUPAC Nomenclature of Carboxylic Acids

11.9K
IUPAC names of carboxylic acids are systematically derived following a few rules discussed below.
For acyclic saturated monocarboxylic acids, the longest hydrocarbon chain containing the –COOH carbon is identified as the parent chain. Then, the last -e of the parent hydrocarbon name is replaced with a suffix -oic acid.
11.9K
Stability of Substituted Cyclohexanes02:30

Stability of Substituted Cyclohexanes

14.5K
This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
14.5K
IUPAC Nomenclature of Aldehydes01:16

IUPAC Nomenclature of Aldehydes

7.3K
Aldehydes are named based on the systematic nomenclature rules set by the IUPAC. For acyclic aldehydes, the longest carbon chain containing the aldehydic (–CHO) group is considered the parent chain. The aldehyde is named by replacing the last letter “e” in the hydrocarbon name with “al”. For instance, a simple, seven-carbon-membered acyclic aldehyde is called heptanal, derived from heptane. The carbon chain is numbered starting from the aldehydic carbon, although the aldehydic...
7.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted Delivery of RNA Therapeutics through Ligand Conjugation.

Bioconjugate chemistry·2026
Same author

Solute Diffusion in Styrenic Triblock Copolymer Organogels.

ACS applied polymer materials·2026
Same author

Antioxidant lipid nanoparticles enhance mRNA stability for regeneration therapy and gene editing.

Nature communications·2026
Same author

Polypeptide-engineered lipid nanoparticles for mRNA delivery with limited immunogenicity.

Nature communications·2026
Same author

Protein-Capturing Microgel-Integrated Microneedle Array Patches for Enhanced Tip-Loading, Storage Stability, and Transdermal Delivery of Recombinant Proteins.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

The Structure and Morphology of Single-Component Oligomeric RNA Delivery Vectors Derived from Amphiphilic Charge-Altering Releasable Transporters.

ACS nano·2025

Related Experiment Video

Updated: Dec 21, 2025

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

9.9K

Cholesterol functionalized aliphatic N-substituted 8-membered cyclic carbonate.

Shrinivas Venkataraman1, Kenneth P Mineart2, Vivek M Prabhu2

  • 1Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669, Singapore.

Polymer Chemistry
|May 15, 2020
PubMed
Summary

Researchers synthesized a cholesterol-functionalized cyclic carbonate monomer (Chol-8m) and used it to create poly(ethylene glycol) (PEG) diblock copolymers. These novel polymers are promising for self-assembled nanostructures and liposome stabilization.

More Related Videos

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

7.2K
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.9K

Related Experiment Videos

Last Updated: Dec 21, 2025

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures
13:38

Synthesis of Biocompatible Liquid Crystal Elastomer Foams as Cell Scaffolds for 3D Spatial Cell Cultures

Published on: April 11, 2017

9.9K
Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

7.2K
Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

1.9K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Cholesterol functionalization is key for biomaterials.
  • Eight-membered cyclic carbonates offer unique polymerization properties.
  • Poly(ethylene glycol) (PEG) is widely used in biomedical applications.

Purpose of the Study:

  • To develop a straightforward synthesis of a cholesterol-functionalized 8-membered cyclic carbonate monomer.
  • To create well-defined poly(ethylene glycol) (PEG) diblock copolymers using this monomer.
  • To explore the potential applications of these novel polymers in nanostructures and liposome stabilization.

Main Methods:

  • Synthesis of cholesterol-functionalized 8-membered cyclic carbonate (Chol-8m) monomer.
  • Organocatalytic ring-opening polymerization of the Chol-8m monomer.
  • Characterization of the resulting poly(ethylene glycol) (PEG) diblock copolymers.

Main Results:

  • Successful and straightforward synthesis of the Chol-8m monomer.
  • Access to well-defined PEG diblock copolymers.
  • Demonstrated potential for self-assembled nanostructures.
  • Showcased utility as steric stabilizers for liposomes.

Conclusions:

  • The developed synthetic route provides efficient access to cholesterol-functionalized cyclic carbonate monomers.
  • The resulting PEG diblock copolymers are versatile building blocks for advanced nanomaterials.
  • These polymers hold significant promise for applications in drug delivery and nanotechnology.