Related Experiment Video

Updated: Dec 21, 2025

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
07:32

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

9.2K

Confounding issues in the "humanized" BAT of mice

Shingo Kajimura1, Bruce M Spiegelman2

  • 1UCSF Diabetes Center and Department of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA. shingo.kajimura@ucsf.edu.

Nature Metabolism
|May 15, 2020
PubMed
Summary

No abstract available in PubMed .

More Related Videos

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
15:24

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

3.7K
Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure
05:34

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

Published on: December 13, 2024

970

Related Experiment Videos

Last Updated: Dec 21, 2025

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System
07:32

A Double Humanized BLT-mice Model Featuring a Stable Human-Like Gut Microbiome and Human Immune System

Published on: August 30, 2019

9.2K
Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors
15:24

Testing Cancer Immunotherapeutics in a Humanized Mouse Model Bearing Human Tumors

Published on: December 16, 2022

3.7K
Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure
05:34

Operating and Biocontainment Procedures of a Facility for Laboratory Mice with a Natural Microbiome: Immunophenotyping Procedure

Published on: December 13, 2024

970

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.3K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.3K

Articles linked to this work by shared authors, journal, and citation graph.

E4BP4 safeguards brown fat mitochondria from obesity-induced fragmentation via ceramide repression.

EMBO reports·2026

SIRT7 Inhibits Adipose Tissue Browning Through Deacetylation of PPARγ2 at K382.

Cells·2026

Brown fat protects against hepatic oxidative stress by remodeling the circulating metabolome.

bioRxiv : the preprint server for biology·2026

Nicotinic Acetylcholine Receptor Signaling Activates Beige Adipocytes and Mediates Systemic Metabolism.

Diabetes·2026

Irisin ameliorates obesity and insulin resistance via adipose tissue IL-33 and regulatory T cells.

Nature metabolism·2026

Microbiota-mediated induction of beige adipocytes in response to dietary cues.

Nature·2026

A data-driven framework reconstructs the molecular continuum of human MASLD progression.

Nature metabolism·2026

Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis.

Nature metabolism·2026

The perineurium integrates leptin with its sympathetic outflow to protect against obesity.

Nature metabolism·2026

Association of GLP-1RA discontinuation and risk of depressive and anxiety disorders in people with type 2 diabetes: a cohort study.

Nature metabolism·2026

Hypoxia rescues complex 1-associated disease caused by proteostatic defects.

Nature metabolism·2026

Lysine pyruvylation couples glycolytic flux to epigenetic regulation.

Nature metabolism·2026

Lateral Continuous Blepharo-Canthoplasty: A Combination of Hotz-Celsus and Lateral Canthus Wedge Resection for the Correction of Entropion and Macroblepharon in Dogs (88 Eyes).

Veterinary ophthalmology·2026

Chiropteran (Hypsugo savii) Post-Natal Brain 2D-In Vitro Models: Primary Cell Isolation, Immortalization and Transcriptomic Changes.

Animals : an open access journal from MDPI·2026

Cross-Species Sex Identification and Comparative Analysis of the SRY Gene in American Mammals.

Animals : an open access journal from MDPI·2026

Comparative diagnostic performance of large language models and clinicians for splenic diseases in dogs and cats.

Veterinary journal (London, England : 1997)·2026

Whole-Mount Immunostaining of Tyrosine Hydroxylase for Dopaminergic Neuron Analysis in Zebrafish Larvae.

Bio-protocol·2026

Detection of Trypanosoma spp. and Leishmania spp. in bats from the department of Atlantico, Colombia.

Revista peruana de medicina experimental y salud publica·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us