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Perinatal Infections: An Important Etiological Risk Factor for Mineralizing Angiopathy

Mahesh Kamate1, Nalla Anuraag Reddy2, Mayank Detroja3

  • 1Division of Pediatric Neurology, Department of Pediatrics, KAHER's Jawaharlal Nehru Medical College, Belagavi, Belgaum, Karnataka, India. drmaheshkamate@gmail.com.

Indian Journal of Pediatrics
|May 15, 2020
PubMed

Insights

Perinatal infections like premature rupture of membranes and neonatal sepsis may cause mineralizing angiopathy in children. This study found a higher prevalence of these infections in affected children compared to controls.

Area of Science:

  • Pediatric Neurology
  • Neonatal Medicine
  • Infectious Diseases

Background:

  • Mineralizing angiopathy is an emerging cause of ischemic stroke in pediatric populations.
  • The etiology of mineralizing angiopathy remains unclear, with congenital and perinatal infections being investigated.
  • Understanding risk factors is crucial for preventing pediatric stroke.

Purpose of the Study:

  • To investigate the prevalence of perinatal infections in children diagnosed with mineralizing angiopathy.
  • To compare the incidence of perinatal infections between children with mineralizing angiopathy, focal cerebral arteriopathy, and non-stroke controls.
  • To identify potential etiological links between perinatal infections and mineralizing angiopathy.

Main Methods:

  • A case-control study involving 16 children with mineralizing angiopathy, 14 with focal cerebral arteriopathy, and 40 non-stroke patients.
  • Detailed parental interviews were conducted to ascertain history of perinatal infections, specifically premature rupture of membranes (PROM) and neonatal sepsis.
  • Statistical analysis was performed to compare infection prevalence across the groups.

Main Results:

  • Perinatal infections were identified in 68.2% (8/16) of children with mineralizing angiopathy, including PROM and neonatal sepsis.
  • None of the children with focal cerebral arteriopathy exhibited a history of perinatal infection.
  • A history of PROM was reported in only 7.5% (3/40) of non-stroke controls, a statistically significant difference compared to the mineralizing angiopathy group.

Conclusions:

  • Perinatal infections, including premature rupture of membranes and neonatal sepsis, are significantly more prevalent in children with mineralizing angiopathy.
  • These findings suggest that perinatal infections may represent an important etiological risk factor for mineralizing angiopathy in pediatric stroke.
  • Further research is warranted to elucidate the precise mechanisms linking perinatal infections to the development of mineralizing angiopathy.

Keywords:
Focal cerebral arteriopathyMineralizing angiopathyPremature rupture of membranesStroke

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