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Transcatheter Aortic Valve Replacement in Aortic Regurgitation
Lulu Liu1, Sai Chen1, Jun Shi1
1Department of Cardiovascular Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
The Annals of Thoracic Surgery
|May 15, 2020
Summary
Transcatheter aortic valve replacement using the J-Valve shows promising safety and efficacy for aortic regurgitation patients. This study indicates acceptable early and midterm clinical outcomes, improving heart function and reducing pulmonary pressure.
Area of Science:
- Cardiology
- Interventional Cardiology
- Cardiac Surgery
Background:
- Limited evidence exists regarding the safety and efficacy of transcatheter aortic valve replacement (TAVR) for patients with aortic regurgitation.
- The J-Valve system is an option for TAVR, but its outcomes in aortic regurgitation patients require further investigation.
Purpose of the Study:
- To evaluate the early and midterm clinical outcomes of TAVR using the J-Valve system in patients with aortic regurgitation.
- To assess the safety and efficacy of this specific TAVR device in this patient population.
Main Methods:
- Analysis of clinical outcomes from the Safety and Efficacy of the J-Valve Ausper System in Patients with Severe Aortic Stenosis and/or Aortic Regurgitation Registry.
- Inclusion of 134 patients with aortic regurgitation treated with the J-Valve at West China Hospital.
Main Results:
- A device success rate of 96.3% was achieved, with a low conversion rate to surgical aortic valve replacement (3.7%).
- Cumulative all-cause mortality was 3% at 30 days and 3.7% at 6 months. Key complications included acute kidney disease (6%) and third-degree atrioventricular block (9%).
- Significant improvements were observed in mean ejection fraction (from 52.1% to 58.7%) and a decrease in mean estimated pulmonary arterial pressure (from 29.3 to 21.5 mm Hg) at 6 months.
Conclusions:
- Transcatheter aortic valve replacement with the J-Valve demonstrates acceptable early and midterm clinical outcomes for patients suffering from aortic regurgitation.
- This large-scale, single-center study supports the use of the J-Valve for TAVR in aortic regurgitation, highlighting its safety and efficacy profile.
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