A molecular perspective on age-dependent changes to the heat shock axis
Rachana Trivedi1, Donald A Jurivich1
1Department of Geriatrics, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, USA.
Experimental Gerontology
|May 15, 2020
Summary
Aging impairs the body's ability to handle stress, affecting cellular function and increasing frailty. This review explores how aging impacts the complex stress response system, involving both its activation and attenuation.
Area of Science:
- Gerontology
- Cellular Biology
- Physiology
Background:
- Aging is characterized by progressive cellular damage, leading to dysfunction, frailty, and increased susceptibility to age-related diseases.
- The ability to cope with physiological stress diminishes significantly with advancing age.
- The stress response, a fundamental biological mechanism, exhibits complex age-dependent alterations.
Purpose of the Study:
- To review the multifaceted influence of aging on the stress axis.
- To examine how age affects both the activating and attenuating pathways of the stress response.
Main Methods:
- Literature review of studies investigating aging and stress response pathways.
- Analysis of age-dependent perturbations in stress axis regulation.
Main Results:
- The age-dependent perturbation of the stress response is more intricate than previously understood.
- Aging influences the stress axis at various levels, impacting both its activation and attenuation mechanisms.
Conclusions:
- Understanding the age-related changes in the stress axis is crucial for addressing frailty and age-related diseases.
- Further research into the complex interplay of aging and stress response pathways is warranted.
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