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Related Concept Videos

Types of RNA01:23

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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
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Regulation of Nuclear Protein Sorting01:45

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Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
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Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
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Related Experiment Video

Updated: Dec 21, 2025

A Chromatin Immunoprecipitation Assay to Identify Novel NFAT2 Target Genes in Chronic Lymphocytic Leukemia
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RNA-Binding Proteins in Acute Leukemias.

Konstantin Schuschel1, Matthias Helwig1, Stefan Hüttelmaier2

  • 1Department of Pediatrics 1, Martin Luther University Halle-Wittenberg, 06120 Halle, Germany.

International Journal of Molecular Sciences
|May 16, 2020
PubMed
Summary

RNA-binding proteins (RBPs) are key regulators in acute leukemias, controlling gene expression post-transcriptionally. This review highlights influential RBPs in leukemia, detailing their functions and clinical relevance.

Keywords:
ALLAMLCPSF6IGF2BPMSI2RBM15-MKL1RNA-binding proteinWT1ZFP36hematopoiesishnRNP Knucleolin

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Area of Science:

  • Molecular biology
  • Hematology
  • Oncology

Background:

  • Acute leukemias arise from genetic alterations disrupting normal blood cell development.
  • Gene expression regulation involves both transcriptional and post-transcriptional mechanisms.
  • RNA-binding proteins (RBPs) critically influence post-transcriptional control of cell fate.

Purpose of the Study:

  • To review the role of influential RNA-binding proteins (RBPs) in acute leukemias.
  • To summarize recent research on RBPs dysregulated in leukemia.
  • To connect RBP function to clinical aspects in acute leukemia.

Main Methods:

  • Literature review of recent research on RBPs in acute leukemias.
  • Analysis of RBP functional domains and affected pathways.
  • Correlation of RBP dysregulation with clinical outcomes.

Main Results:

  • RBPs are implicated in acute leukemias through dysregulation or as part of fusion proteins.
  • RBPs control critical cellular processes like RNA localization and translation.
  • Specific RBPs exhibit altered functions contributing to leukemogenesis.

Conclusions:

  • RBPs are vital post-transcriptional regulators in acute leukemia pathogenesis.
  • Understanding RBP roles offers insights into leukemia molecular mechanisms.
  • Targeting RBPs may present novel therapeutic strategies for acute leukemias.