New Synthesis for the Monobactam Antibiotic-LYS228
Zhongbo Fei1, Quanbing Wu1, Lei Li1
1Chemical and Analytical Development, Suzhou Novartis Pharma Technology Company Ltd., Changshu, Jiangsu 215537, China.
The Journal of Organic Chemistry
|May 16, 2020
Abstract:
A new synthesis of LYS228, fitting for further process development for commercial manufacture, is described. The key features of this synthesis include development of new protocols for acylation reactions, application of an asymmetric hydrogenation via dynamic kinetic resolution, and a late-stage ring closure to form β-lactam 1.
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