Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Physiological Barriers

Physiological Barriers

Physiological barriers are semi-permeable cellular structures restricting drug diffusion into intracellular compartments and tissues. There are six types of physiological barriers: blood endothelial, cell membrane, blood-brain, blood-cerebrospinal fluid (CSF), blood-placenta, and blood-testis barriers.
The blood endothelial barrier is the most porous of these. It allows all small ionized, un-ionized, and lipophilic molecules to pass through the endothelial lining into the interstitial space...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Design and Control of Reduced Power Actuation for Active-Contracting Orthostatic Intolerance Garments.

International Conference on Environmental Systems. American Institute of Aeronautics and Astronautics·2020

Same author

Medical Compression Capabilities of Contractile SMA Knitted Actuators.

SMST : proceedings of the International Conference on Shape Memory and Superelastic Technologies. International Conference on Shape Memory and Superelastic Technologies·2020

Same author

Morphing Compression Garments for Space Medicine and Extravehicular Activity Using Active Materials.

Aerospace medicine and human performance·2016

Same author

Quantification of adverse events associated with functional MRI scanning and with real-time fMRI-based training.

International journal of behavioral medicine·2011

Same author

Citicoline affects appetite and cortico-limbic responses to images of high-calorie foods.

The International journal of eating disorders·2009

Same author

Prediction of cognitive decline after stroke using proton magnetic resonance spectroscopy.

Journal of the neurological sciences·2006

Search research articles

Related Experiment Video

Updated: Dec 21, 2025

Deposition of Porous Sorbents on Fabric Supports

Deposition of Porous Sorbents on Fabric Supports

Published on: June 12, 2018

Dynamic Countermeasure Fabrics for Post-Spaceflight Orthostatic Intolerance.

Rachael M Granberry, Kevin P Eschen, Amy J Ross

Aerospace Medicine and Human Performance

|May 16, 2020

Summary

This summary is machine-generated.

Shape memory alloy (SMA) knitted actuators offer a novel solution for aerospace orthostatic intolerance garments (OIG), providing dynamic compression without mobility restriction. This technology promises improved comfort and therapeutic pressure for astronauts and potentially terrestrial applications.

More Related Videos

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Published on: December 11, 2013

Related Experiment Videos

Last Updated: Dec 21, 2025

Deposition of Porous Sorbents on Fabric Supports

Deposition of Porous Sorbents on Fabric Supports

Published on: June 12, 2018

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Published on: December 11, 2013

Area of Science:

Biomedical Engineering
Materials Science
Aerospace Medicine

Background:

Traditional aerospace orthostatic intolerance garments (OIG) are often pneumatic, limiting mobility and requiring external air supplies.
Existing elastic compression garments present usability challenges, including difficulty in donning/doffing and discomfort due to constant compression.

Purpose of the Study:

To evaluate novel contractile shape memory alloy (SMA) knitted actuators for developing low-profile, dynamic compression OIG.
To assess the functional capabilities and compression potential of SMA knitted actuators for aerospace applications.

Main Methods:

Displacement control testing of 10 SMA actuator samples with varying geometric parameters.
Thermal cycling under different structural strains (0-45%) to measure inactive and actuated forces.
Approximation of compression capabilities using medical hosiery standards and aerospace population anthropometric data (ANSUR 2012).

Main Results:

Predicted dynamic compression reached 52 mmHg (single layer) and 105 mmHg (double layer) at the ankle.
Low inactive pressures (<20 mmHg) confirmed controllable compression.
Actuation increased pressure up to 33 mmHg (single layer) and 67 mmHg (double layer).

Conclusions:

SMA knitted actuators show potential for low-profile, dynamic compression garments to manage orthostatic intolerance in aerospace.
This technology offers therapeutic pressures suitable for astronauts and has potential for terrestrial medical and high-performance aircraft use.