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Nitrogen-doped MoS2 quantum dots: Facile synthesis and application for the assay of hematin in human blood
Feng-Yi Wu1, Yuan-Sheng Cheng2, Dong-Mei Wang3
1College of Chemistry and Materials Science, Key Laboratory of Functional Molecular Solids, The Ministry of Education, Anhui Laboratory of Molecular-Based Materials, Anhui Key Laboratory of Functional Molecular Solids, Anhui Normal University, Wuhu 241000, PR China; School of Chemistry and Material Engineering, Institute of Novel Functional Materials, Chaohu University, Hefei 238000, PR China.
Abstract:
Nitrogen-doped MoS2 quantum dots (N-MoS2 QDs) were synthesized via a facile hydrothermal approach, and exhibited high fluorescence quantum yield (QY, 14.9%), excellent photostability, biocompatibility and water solubility. A novel method with good selectivity and sensitivity was established to assay hematin using N-MoS2 QDs as a fluorescent probe based on inner filter effect (IFE). Fluorescent quenching of N-MoS2 QDs has a fine linear dependence with the concentration of hematin in the range of 0.5-15 μmol/L and a limit of detection of 0.32 μmol/L (S/N = 3). By the detection method, average concentration of hematin in real health human erythrocytes was measured as 22.5 ± 3.9 μmol/L. And, recoveries range varied from 94 to 108% through standard recovery experiment. The N-MoS2 QDs probe shows excellent photostability, low cytotoxicity and anti-interference ability for hematin assay, which may become a promising method for the test of hematin in human blood.
