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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

240
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
240
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

222
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
222
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

729
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
729
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

251
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
251
Tissue Transplantation01:24

Tissue Transplantation

798
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

266
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Related Experiment Video

Updated: Dec 21, 2025

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
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Hematopoietic stem cell donor with IgA nephropathy: Challenges and management algorithm.

Ram V Nampoothiri1, Vivek Kumar2, Joyita Bharati2

  • 1Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|May 16, 2020
PubMed
Summary
This summary is machine-generated.

Donor safety in hematopoietic cell transplants is crucial. For donors with IgA nephropathy, a management plan was proposed for peripheral blood stem cell harvest, addressing suitability concerns.

Keywords:
ApheresisG-CSFHematopoietic cell donorIgA nephropathy

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Area of Science:

  • Nephrology
  • Hematology
  • Transplantation Science

Background:

  • Donor safety is paramount in allogeneic hematopoietic cell transplantation (HCT).
  • Consensus guidelines exist for related adult donor suitability, particularly concerning pre-existing renal conditions.
  • Granulocyte colony-stimulating factor (G-CSF) is used to mobilize peripheral blood stem cells but carries a theoretical risk of immune flare-up.

Observation:

  • A related donor with a history of IgA nephropathy (IgAN) desired peripheral blood stem cell (PBSC) harvest.
  • This presented a unique challenge to established donor suitability criteria.
  • Standard recommendations favor bone marrow harvest for donors with immune-mediated glomerulonephritis.

Findings:

  • The case highlights a conflict between donor preference and established safety protocols.
  • A specific management plan was developed to address the donor's IgAN history and preference for PBSC harvest.
  • This plan aimed to mitigate theoretical risks associated with G-CSF in the context of IgAN.

Implications:

  • The proposed management plan offers a potential strategy for handling similar complex donor suitability cases.
  • It emphasizes the need for individualized assessment in HCT donor selection.
  • This approach could inform future guidelines on donor management for patients with specific renal conditions undergoing HCT.