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Obtaining Highly Purified Toxoplasma gondii Oocysts by a Discontinuous Cesium Chloride Gradient
Published on: November 3, 2009
rTgOWP1-f, a specific biomarker for Toxoplasma gondii oocysts
Susana Sousa1,2,3, André Almeida4, Lurdes Delgado5
1Center for Parasite Biology and Immunology, National Institute of Health Dr Ricardo Jorge, Rua Alexandre Herculano 321, 4000-055, Porto, Portugal. adelaide.sousa@insa.min-saude.pt.
Abstract:
Toxoplasma gondii oocyst wall protein 1 (TgOWP1) integrates a family of seven proteins, consensually assumed as specific antigens of Toxoplasma gondii oocyst stage, located in the outer layer of the oocyst wall. Herein, we notice the expression of a recombinant antigen, rTgOWP1-f, derived from a fragment selected on basis of its structural homology with Plasmodium MSP1-19. Rabbit polyclonal antibodies anti-rTgOWP1-f evidence ability for specific identification of environmental T. gondii oocysts. We assume, rTgOWP1-f, as a possible biomarker of oocysts. In addition, we present findings supporting this vision, including the development of an immunodetection method for T. gondii oocysts identification.
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