Effect of Electroacupuncture and Counseling on Sub-Threshold Depression: A Study Protocol for a Multicenter...

Area of Science:

• Integrative Medicine
• Mental Health Research
• Clinical Trials

Background:

• Sub-threshold depression is prevalent and poses a risk for major depression.
• Existing evidence for electroacupuncture (EA) and counseling is limited by small sample sizes.
• There is a need to evaluate the comparative effectiveness of these interventions.

Purpose of the Study:

• To compare the effectiveness of EA, counseling, and their combination for treating sub-threshold depression.
• To investigate the underlying mechanisms of these therapeutic interventions.
• To provide robust evidence for clinical practice guidelines.

Main Methods:

• A multicenter, randomized, single-blind clinical trial involving 138 participants.
• Interventions included EA (3x/week), counseling (1x/week), and combination therapy over 6 weeks.
• Primary outcomes measured using Hamilton Depression Scale (HAMD-17) and Beck Depression Inventory (BDI-II).

Main Results:

• This section is to be filled once the study is completed and results are available.
• The study is designed to provide statistically significant data on treatment efficacy.
• Analysis will focus on changes in depression scores and other secondary measures.

Conclusions:

• This trial will compare the efficacy of electroacupuncture, counseling, and combination therapy for sub-threshold depression.
• The findings aim to clarify the most effective treatment approach.
• Further research into treatment mechanisms will be explored.