Related Experiment Video

Updated: Dec 21, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

8.7K

Macrophage-Based Therapies for Atherosclerosis Management

Renyi Peng1,2, Hao Ji1,2, Libo Jin1,2

  • 1Institute of Life Sciences, Wenzhou University, Wenzhou, Zhejiang 325035, China.

Journal of Immunology Research
|May 16, 2020
PubMed

Insights

Macrophages offer a promising avenue for treating atherosclerosis (AS), a chronic inflammatory vascular disease. Macrophage-based therapies show potential for effective and safe AS management in future clinical applications.

Area of Science:

  • Vascular Biology
  • Immunology
  • Drug Delivery Systems

Background:

  • Atherosclerosis (AS) is a chronic inflammatory vascular disease underlying ischemic cardio/cerebrovascular disease (CVD).
  • Current long-term treatments for AS exhibit limited efficacy and significant side effects.
  • Macrophages possess intrinsic homing capabilities, presenting an opportunity for targeted and safer AS management.

Purpose of the Study:

  • To systematically review macrophage-based therapeutic strategies for atherosclerosis management.
  • To explore novel approaches utilizing macrophages or their components for AS treatment.

Main Methods:

  • Review of current literature on macrophage-based therapies for AS.
  • Analysis of strategies including macrophage autophagy, polarization, and targeted delivery.
  • Examination of microenvironment-triggered drug release and macrophage/membrane-based drug carriers.

Main Results:

  • Macrophage-based therapies demonstrate significant potential for AS management.
  • Various approaches leverage macrophage characteristics for targeted drug delivery and controlled release.
  • The use of macrophages or their membranes as drug carriers is a developing area.

Conclusions:

  • Macrophage-based therapies hold considerable promise for effective AS management.
  • These strategies offer potential for improved safety and efficacy compared to conventional treatments.
  • Further research and clinical translation are anticipated for macrophage-based AS therapies.

More Related Videos

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages09:57

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

Published on: August 12, 2019

10.0K
Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis08:01

Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

7.6K

Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
261
Inflammation01:38

Inflammation

Overview
61.1K
Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
270
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
647
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
175
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
173