Optimizing outcomes for keratoplasty in ectatic corneal disease
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Updated: Dec 21, 2025
Corneal Donor Tissue Preparation for Descemet's Membrane Endothelial Keratoplasty
Published on: September 17, 2014
Angeli Christy Yu1,2,3, Leila Mattioli2,3, Massimo Busin1,2,3
1Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara.
Purpose Of Review:
Advanced keratectasia often requires corneal transplantation for restoration of vision. This review discusses the surgical approach suitable for these cases including significant updates in the current literature.
Recent Findings:
With greater understanding of ectatic corneal disease and its associated operative challenges, several modifications in the surgical approach have been developed. Identified predictive factors for successful pneumatic dissection and intraoperative complications have informed surgical planning and decision-making. In the setting of failed pneumatic dissection, sequential use of alternative lamellar dissection techniques is a reasonable surgical strategy. Surgical refinements to optimize visual outcomes and postoperative interventions to correct residual refractive errors have improved visual rehabilitation after keratoplasty.
Summary:
With evidence of its undisputed advantages, DALK has been widely recognized as the primary surgical option for ectatic corneal disease.
