Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pathophysiology of Vomiting

Pathophysiology of Vomiting

Vomiting is a complex physiological response to expel harmful or irritating substances from the body. It's a defensive mechanism triggered by stimuli like poisons, microbial toxins, cytotoxic drugs, and mechanical abdominal distension. The process is centrally coordinated by the vomiting (or emetic) center located in the medulla of the brainstem. This area, rich in muscarinic M1, histamine H1, neurokinin 1 (NK1), and serotonin 5-HT3 receptors, coordinates the act of vomiting through...

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Chemotherapy-Induced Nausea and Vomiting: Dopamine Receptor Antagonists

Dopamine receptor antagonists, also known as antipsychotic agents, are critical in managing chemotherapy-induced vomiting. These antiemetic agents block dopamine receptors in the chemoreceptor trigger zone (CTZ), inhibiting signal transmission to the vomiting center. Antipsychotic agents encompass phenothiazines (PTZ), butyrophenones, benzamides, and thienobenzodiazepines (Zyprexa), which are utilized for their antiemetic and sedative properties.
Phenothiazines, such as prochlorperazine...

Other Disorders of Digestive System

Other Disorders of Digestive System

The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...

Bulimia Nervosa

Bulimia Nervosa

Bulimia nervosa is a complex and severe eating disorder characterized by a cyclical pattern of binge-and-purge eating pattern. It generally involves an episode of binge eating, followed by compensatory behaviors such as vomiting, excessive exercise, laxative use, or fasting, to prevent weight gain. Despite often maintaining a normal weight, individuals with bulimia are intensely preoccupied with their body image and harbor an overwhelming fear of gaining weight. This can contribute to the...

Prevention of Further Absorption of Poison

Prevention of Further Absorption of Poison

In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Face-To-Face Vs. Online Behavioral Parent Training for Young Children with ADHD: Child and Parent Outcomes.

Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53·2026

Same author

A 'good' regulator may provide a world model for intelligent systems.

Philosophical transactions. Series A, Mathematical, physical, and engineering sciences·2026

Same author

Neurochemical and Neurophysiological Effects of Intravenous Administration of <i>N,N</i>-Dimethyltryptamine in Rats.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025

Same author

Intravenous Administration of Serotonergic Psychedelics Produce Short-lasting Changes in Sleep-Wake Behavior and High Gamma Functional Connectivity in Rats.

bioRxiv : the preprint server for biology·2025

Same author

Intravenous psilocybin induces dose-dependent changes in functional network organization in rat cortex.

Translational psychiatry·2025

Same author

Tetrodotoxin-mediated inactivation of medial prefrontal cortex decreases wakefulness and rapid eye movement sleep, and increases slow-wave sleep in rat.

Sleep·2024

Search research articles

Related Experiment Video

Updated: Dec 21, 2025

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Published on: September 11, 2018

Vomiting Children: It's Not Always Gastroenteritis.

Madeline Mier, Amanda Nelson, Leah Finkel

Pediatric Annals

|May 16, 2020

Summary

This summary is machine-generated.

Pediatric emesis without diarrhea requires careful diagnosis. Consider trauma, increased intracranial pressure, obstruction, or diabetic ketoacidosis for persistent vomiting in children.

More Related Videos

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture

Published on: August 4, 2023

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

Related Experiment Videos

Last Updated: Dec 21, 2025

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Published on: September 11, 2018

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture

Author Spotlight: Alleviating Nausea and Vomiting in Pregnancy with Safe and Effective Auricular Acupuncture

Published on: August 4, 2023

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Detection and Genogrouping of Noroviruses from Children's Stools By Taqman One-step RT-PCR

Published on: July 22, 2012

Area of Science:

Pediatric Gastroenterology
Pediatric Emergency Medicine

Background:

Emesis is a frequent pediatric symptom.
Vomiting without diarrhea in children warrants thorough evaluation, especially if prolonged beyond 24 hours.

Purpose of the Study:

To outline the differential diagnosis of pediatric emesis without diarrhea.
To emphasize the importance of prompt recognition and management.

Main Methods:

This review synthesizes information on the diagnostic considerations for pediatric emesis.
It highlights key conditions that must be ruled out.

Main Results:

Differential diagnoses include trauma, elevated intracranial pressure, and intestinal obstruction.
Metabolic disturbances, such as diabetic ketoacidosis, are also critical considerations.

Conclusions:

Prompt identification and management of the underlying cause of pediatric emesis are essential.
A broad differential diagnosis approach is crucial for effective treatment.