Successful Coronary Angiography Following Rapid Intravenous Desensitization for Refractory Contrast Allergy

Most allergic reactions to radiocontrast media can be managed with a pretreatment protocol of steroids and antihistamines. However, in rare circumstances, patients can have severe allergic symptoms despite pretreatment. In this case, we highlight the use of a novel desensitization protocol in a patient with a severe breakthrough contrast allergy and unstable angina that allowed for successful percutaneous coronary intervention. The protocol was well tolerated, feasible, and might allow other patients with similar allergies to undergo angiography and imaging studies successfully that require the use of radiocontrast media.