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Drug Repurposing and DNA Damage in Cancer Treatment: Facts and Misconceptions

Eleni Sertedaki1, Athanassios Kotsinas1

  • 1Molecular Carcinogenesis Group, Lab Histology-Embryology, Faculty of Medicine, National Kapodistrian University of Athens, 11527 Athens, Greece.

Cells
|May 17, 2020
PubMed

Insights

Drug repurposing offers new anticancer agents. Disulfiram (Antabuse) shows anticancer effects by causing DNA damage, a newly uncovered mechanism.

Area of Science:

  • Oncology
  • Pharmacology
  • Drug Discovery

Background:

  • Drug repurposing is a viable strategy for identifying novel anticancer agents.
  • Repurposed drugs offer benefits like faster clinical trial efficacy assessment and established safety profiles.
  • Targeting specific tumor types requires a deep understanding of drug mechanisms of action.
Keywords:
DNA damagecancerdisulfiramdrug repurposing

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