Related Experiment Video

Updated: Dec 21, 2025

Isolation and Identification of Extravascular Immune Cells of the Heart
08:24

Isolation and Identification of Extravascular Immune Cells of the Heart

Published on: August 23, 2018

13.8K

Physiological and Pathological Functions of CARD9 Signaling in the Innate Immune System

Larsen Vornholz1,2, Jürgen Ruland3,4,5,6

  • 1TUM School of Medicine, Institute of Clinical Chemistry and Pathobiochemistry, Technical University of Munich, 81675, Munich, Germany.

Current Topics in Microbiology and Immunology
|May 17, 2020
PubMed

Insights

Caspase recruitment domain protein 9 (CARD9) is crucial for innate immunity, mediating defense against pathogens and regulating inflammation. CARD9 signaling impacts immune homeostasis, cancer immunity, and is linked to human immune disorders.

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Signaling

Background:

  • Caspase recruitment domain protein 9 (CARD9) is a key adaptor protein in innate immunity.
  • CARD9 integrates signals from C-type lectin receptors and intracellular pattern recognition receptors.
  • Dysregulation of CARD9 signaling is implicated in various immune-mediated diseases.

Purpose of the Study:

  • To review the current understanding of CARD9 signaling pathways.
  • To summarize the physiological and pathological roles of CARD9.
  • To discuss the implications of CARD9 in human immune-mediated diseases.

Main Methods:

  • Literature review of CARD9 signaling.
  • Analysis of CARD9's role in host defense mechanisms.
  • Examination of CARD9's involvement in inflammatory and immune responses.

Main Results:

  • CARD9 signaling is essential for antifungal immunity and contributes to immunity against bacteria, viruses, and parasites.
  • CARD9 pathways regulate sterile inflammatory responses and influence anti-tumor immunity.
  • Genetic alterations in CARD9 are associated with primary immunodeficiencies and inflammatory disorders.

Conclusions:

  • CARD9 is a central regulator of innate immunity with diverse roles in host defense and inflammation.
  • Understanding CARD9 signaling is critical for developing therapeutic strategies for immune-mediated diseases.
  • Further research into CARD9 pathways can elucidate mechanisms underlying immunodeficiency and inflammatory conditions.

More Related Videos

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity07:09

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

7.8K
Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling09:51

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

12.8K

Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
15.6K
Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
6.2K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
9.7K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
83.0K
Paracrine Signaling01:21

Paracrine Signaling

Paracrine signaling allows cells to communicate with their immediate neighbors via secretion of signaling molecules. Such a signal can only trigger a response in nearby target cells because the signal molecules degrade quickly or are inactivated if not taken up. Prominent examples of paracrine signaling include nitric oxide signaling in blood vessels, synaptic signaling of neurons, the blood clotting system, tissue repair/wound healing, and local allergic skin reactions. Nitric oxide as a...
59.0K
The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
7.8K