Changes in ocular biometric parameters after renal transplantation.

Area of Science:

• Ophthalmology
• Nephrology
• Transplantation Surgery

Background:

• End-stage renal disease (ESRD) patients often require renal transplantation.
• Ocular biometric parameters can be affected by systemic conditions and treatments.
• Understanding these changes is crucial for accurate refractive error prediction in ESRD patients undergoing transplantation.

Purpose of the Study:

• To investigate the postoperative changes in ocular biometric parameters in patients with ESRD following renal transplantation.
• To assess the impact of renal transplantation on measurements such as axial length, corneal thickness, anterior chamber depth, and lens thickness.
• To evaluate the effect of these biometric changes on refractive prediction error for intraocular lens (IOL) power calculations.

Main Methods:

• Retrospective study of 33 eyes from 33 ESRD patients who underwent renal transplantation.
• Ocular biometric measurements included axial length (AL), central corneal thickness (CCT), anterior chamber depth (ACD), corneal keratometry (K1, K2), astigmatism, lens thickness (LT), and intraocular pressure (IOP).
• Refractive prediction error (RE) was calculated pre- and post-transplantation using the same IOL power for potential cataract surgery evaluation.

Main Results:

• Statistically significant differences were observed in AL, LT, ACD, and CCT one month post-transplantation (p < 0.001).
• No significant changes were found in corneal keratometry (K1, K2) or degree of astigmatism (p > 0.05).
• Refractive prediction error remained statistically insignificant (p = 0.61), indicating stable refractive outcomes.

Conclusions:

• Renal transplantation leads to significant changes in ocular biometry, including decreased AL, LT, and CCT, and increased ACD.
• Despite these biometric shifts, corneal keratometry, astigmatism, and intraocular pressure remain largely unaffected.
• These alterations do not significantly impact IOL power calculations, ensuring predictable refractive outcomes for subsequent cataract surgery in ESRD patients.