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Related Concept Videos

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Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

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Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Related Experiment Video

Updated: Dec 21, 2025

Planar and Three-Dimensional Printing of Conductive Inks
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Formulation design for inkjet-based 3D printed tablets.

Koyel Sen1, Arushi Manchanda1, Tanu Mehta1

  • 1Department of Pharmaceutical Sciences, University of Connecticut, United States.

International Journal of Pharmaceutics
|May 17, 2020
PubMed
Summary
This summary is machine-generated.

Binder-jet 3D printing achieved efficient drug loading for Amitriptyline Hydrochloride tablets. This 3D printing method offers precise control over drug delivery and tablet properties.

Keywords:
3D printingAdditive manufacturingBinder-jet 3D printingDrug loading efficiency

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Area of Science:

  • Pharmaceutical Technology
  • 3D Printing in Medicine
  • Drug Delivery Systems

Background:

  • 3D printing offers novel manufacturing routes for personalized medicine.
  • Binder-jet 3D printing is explored for pharmaceutical applications.
  • Controlling drug loading and release is crucial for effective oral dosage forms.

Purpose of the Study:

  • To evaluate drug loading efficiency using binder-jet 3D printing.
  • To assess the printability of active pharmaceutical ingredient (API) ink solutions.
  • To characterize the physicochemical and performance properties of 3D printed tablets.

Main Methods:

  • Binder-jet 3D printing process utilized for tablet fabrication.
  • Ohnesorge number calculated to assess ink printability.
  • Pre-formulation studies included thermal analysis and compendial tests.
  • Characterization involved weight variation, hardness, disintegration, size, SEM-EDS, and micro-CT.
  • Dissolution studies were performed using a modified USP apparatus II.

Main Results:

  • High drug loading efficiency achieved with minimal variation (<0.26% RSD).
  • SEM-EDS confirmed uniform API distribution within the printed tablets.
  • Micro-CT imaging revealed a porous surface structure.
  • Printed tablets exhibited immediate release characteristics in dissolution studies.

Conclusions:

  • Binder-jet 3D printing is a viable method for producing drug-loaded tablets with controlled properties.
  • The study demonstrates successful incorporation and uniform distribution of Amitriptyline Hydrochloride.
  • The characterized printed tablets show potential for immediate drug release applications.