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Updated: Dec 21, 2025
09:58
Investigating the Three-dimensional Flow Separation Induced by a Model Vocal Fold Polyp
Published on: February 3, 2014
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Paradoxical Vocal Fold Movement: A Retrospective Analysis.
Dylan Vance1, Cameron Heyd2, Matthew Pier1
1Drexel University College of Medicine.
Summary
Paradoxical vocal fold motion (PVFM) is a rare disorder causing breathing difficulties. A combination of botulinum toxin, voice therapy, and reflux treatment significantly improved patient symptoms.
Area of Science:
- Laryngology
- Respiratory Medicine
- Speech-Language Pathology
Background:
- Paradoxical vocal fold motion (PVFM) involves inappropriate vocal fold closure during inhalation, leading to episodic dyspnea.
- Diagnosis requires a comprehensive evaluation including history, physical exam, laryngoscopy with provocative maneuvers, and laryngeal electromyography.
- The exact pathogenesis and clinical presentation of PVFM remain unclear.
Purpose of the Study:
- To characterize patients diagnosed with PVFM.
- To assess the effectiveness of current therapeutic interventions for PVFM.
Main Methods:
- A retrospective chart review was conducted on 40 PVFM patients from January 2007 to August 2019.
- Data analyzed included comorbidities, lab tests, imaging, 24-hour pH impedance testing, and laryngeal EMG.
- The Dyspnea Index questionnaire was used pre- and post-treatment to evaluate efficacy.
Main Results:
- The study cohort averaged 30.25 years, with 45% under 18 and 80% female. Serious athletes and students comprised 25% and 40%, respectively.
- Comorbidities included asthma (65%) and psychiatric diagnoses (33%). No family history of PVFM was noted.
- A regimen of botulinum toxin, voice therapy (VT), and laryngopharyngeal reflux (LPR) treatment yielded a 90% subjective improvement rate.
Conclusions:
- The combination of botulinum toxin, VT, and LPR treatment is the most effective management strategy for PVFM currently.
- Further research is necessary to elucidate the underlying etiology of paradoxical vocal fold motion disorder.
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