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Related Experiment Video

Updated: Dec 21, 2025

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Emerging Treatment Options for Migraine.

Yi Jing Zhao¹, Jonathan J Y Ong, Peter J Goadsby

¹Department of Neurology, National Neuroscience Institute (Singapore General Hospital Campus), Singapore.

Annals of the Academy of Medicine, Singapore

|May 19, 2020

Summary

New migraine treatments offer improved options for patients. Emerging therapies target the calcitonin gene-related peptide (CGRP) pathway and serotonin receptors, alongside non-invasive neuromodulation, providing better tolerated and effective migraine relief.

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Area of Science:

Neurology
Pharmacology
Medical Devices

Background:

Migraine is a leading cause of disability, affecting 1 billion people globally.
Current migraine treatments have limitations, including side effects and poor tolerability.
Advances in understanding migraine pathophysiology have enabled targeted treatment development.

Purpose of the Study:

To review emerging therapeutic options for migraine management.
To discuss novel treatments targeting the calcitonin gene-related peptide (CGRP) pathway.
To explore alternative treatments such as serotonin 5-HT_1F receptor agonists and neuromodulation.

Main Methods:

Review of recent scientific literature on migraine pathophysiology and treatment.
Analysis of new drug classes including gepants and CGRP monoclonal antibodies.
Evaluation of serotonin 5-HT_1F receptor agonists (ditans) for acute treatment.
Assessment of non-invasive neuromodulation techniques.

Main Results:

The calcitonin gene-related peptide (CGRP) pathway is a key target for novel migraine therapies.
Gepants and CGRP monoclonal antibodies represent new classes of preventive and acute treatments.
Ditans offer a new option for acute migraine management.
Non-invasive neuromodulation provides a well-tolerated alternative for some patients.

Conclusions:

Recent years have seen significant advancements in migraine treatment options.
Targeted therapies focusing on the CGRP pathway and serotonin receptors offer improved efficacy and tolerability.
Non-invasive neuromodulation presents a valuable, low-side-effect option for migraine sufferers.