Network structure of psychotic-like experiences in adolescents: Links with risk and protective factors

The main goal was to analyse the network structure of psychotic-like experiences (PLEs) in a large sample of adolescents. In addition, the network structure between PLEs and putative risk (mental health difficulties, suicidal behaviour, depression symptoms) and protective factors (prosocial behaviour, subjective well-being, self-esteem) for psychosis was analysed.

The sample compromised a total of 1790 adolescents (M=15.7 years; SD=1.26), 816 men (45.6%), selected by stratified random cluster sampling. Various tools were used to measure PLEs, general psychopathology, suicide ideation and behaviour, depression symptoms, prosocial behaviour, subjective well-being, and self-esteem. The Gaussian graphical model for continuous variables and Ising model for binary variables were used for network estimation.

The PLEs estimated network was strongly interconnected. Unusual perceptual experiences were among the most central nodes. The average predictability of this network was 16.41%. The PLEs and risk and protective factors estimated network showed a high degree of interconnectedness between PLEs and psychopathology domains. PLEs, behavioural problems, and emotional symptoms were among the most central nodes. The mean predictability of this network was 43.46%. The results of the stability and accuracy analysis indicated that networks were accurately estimated.

At population level, extended psychosis phenotype can be conceptualized as a network of interacting cognitive, emotional, and behavioural features. The network model allows us to understand psychosis risk, at the same time opening new lines of study in the mental health arena.