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Congenital afibrinogenemia in a 4-year-old girl complicated with acute lymphoblastic leukemia

Alper Özcan1, Bahadır Samur1, Şefika Akyol1

  • 1Division of Pediatric Hematology Oncology, Department of Pediatrics, Erciyes University Faculty of Medicine, Kayseri, Turkey.

The Turkish Journal of Pediatrics
|May 19, 2020
PubMed

Insights

Congenital fibrinogen deficiency, a rare inherited bleeding disorder, poses life-threatening risks when complicated by hematological malignancies like leukemia. This case highlights management strategies for such complex scenarios.

Area of Science:

  • Hematology
  • Genetics
  • Oncology

Background:

  • Congenital fibrinogen deficiency is a rare inherited coagulation disorder.
  • Co-occurrence of congenital fibrinogen deficiency and hematological malignancy presents significant life-threatening risks.

Observation:

  • A four-year-old female patient diagnosed with congenital fibrinogen deficiency presented with acute lymphoblastic leukemia.

Findings:

  • This case report focuses on the therapeutic strategies for managing afibrinogenemia in patients with co-existing acute leukemia.
  • Effective management requires a multidisciplinary approach addressing both the bleeding disorder and the hematological malignancy.

Implications:

  • Highlights the importance of tailored treatment protocols for rare bleeding disorders in pediatric oncology.
  • Informs clinical practice regarding the complex management of afibrinogenemia and leukemia.
  • Emphasizes the need for further research into optimal therapeutic interventions for this rare patient population.
Abstract

Keywords:
acute lymphoblastic leukemiachildcongenital afibrinogenemia

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