Related Experiment Video
Updated: Dec 21, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
Sofosbuvir as a potential option for the treatment of COVID-19
Anahid Nourian1, Hossein Khalili2
1. anahid.nouriam@gmail.com.
Abstract:
Sofosbuvir may be a potential option in the treatment of COVID-19 based on the similarity between the replication mechanisms of the HCV and the coronavirus. According the limited experimental evidences, it is hypothesized that sofosbuvir might be a potential option to improve care of patients with COVID-19 especially at the start of the disease and before invasion of the virus into the lung parenchymal cells. Efficacy and safety of sofosbuvir in treatment of COVID-19 may be considered in future clinical studies.
Related Concept Videos
Subviral Agents
Cystic Fibrosis: Management
Sinus disease and chronic...
Pharmacokinetics: Drug–Food and Drug–Viral Interactions
Retroviruses
siRNA - Small Interfering RNAs
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...

