Jove
Visualize
Contact Us

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.1K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.0K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.0K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

886
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
886
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

8.4K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A bivalent multi-epitope vaccine targeting CSP and TRAP of Plasmodium vivax designed through immunoinformatics and structural bioinformatics.

BMC microbiology·2026
Same author

Computational identification of putative GyrA and AcrR inhibitors from gut microbiota and natural products targeting multidrug-resistant Salmonella enterica.

Scientific reports·2026
Same author

Molecular profiling and computational mutational analysis of bla-NDM-1 in clinical Acinetobacter baumannii isolates.

BMC microbiology·2026
Same author

Computational immunoinformatics and molecular modeling approaches for designing a multi-epitope vaccine against Babesia microti.

BMC microbiology·2026
Same author

Spatiotemporal patterns and forecasted trends of dengue in Saudi Arabia: a national surveillance study, 2012-2024.

BMC infectious diseases·2026
Same author

Phytochemicals from Astragalus zederbaueri as Acetylcholinesterase Inhibitors for Alzheimer's Therapy.

PloS one·2026
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Dec 21, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.7K

An Insight into Primary Congenital Glaucoma.

Muhammad Umer Khan1, Musabih Ul Qayyum Zia1, Wajeeha Tabassum1

  • 1University Institute of Medical Lab Technology, Faculty of Allied Health Sciences, University of Lahore, Lahore, Pakistan.

Critical Reviews in Eukaryotic Gene Expression
|May 19, 2020
PubMed
Summary

Primary congenital glaucoma (PCG) is a rare childhood eye disease causing blindness. Genetic defects in the trabecular meshwork lead to increased intraocular pressure and vision loss in affected newborns and young children.

More Related Videos

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.7K
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.4K

Related Experiment Videos

Last Updated: Dec 21, 2025

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.7K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.7K
Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments
08:55

Translaminar Autonomous System Model for the Modulation of Intraocular and Intracranial Pressure in Human Donor Posterior Segments

Published on: April 24, 2020

3.4K

Area of Science:

  • Ophthalmology
  • Genetics
  • Pediatrics

Background:

  • Glaucoma is a leading cause of vision impairment globally, with primary congenital glaucoma (PCG) affecting newborns and young children.
  • PCG, a significant cause of childhood blindness, has an unknown etiology and varying prevalence across populations.
  • This condition results from genetic defects in the eye's trabecular meshwork, leading to elevated intraocular pressure (IOP).

Purpose of the Study:

  • To summarize the current understanding of primary congenital glaucoma (PCG) as a cause of childhood blindness.
  • To highlight the genetic basis, clinical manifestations, and treatment of PCG.
  • To emphasize the need for early detection and resource allocation to prevent avoidable blindness.

Main Methods:

  • Review of existing literature on primary congenital glaucoma.
  • Analysis of genetic loci and associated genes implicated in PCG.
  • Discussion of clinical presentation, diagnostic methods, and treatment options.

Main Results:

  • PCG is an autosomal recessive disorder linked to genetic mutations at loci GLC3A (CYP1B1), GLC3B, GLC3C, and GLC3D (LTPB2).
  • Symptoms include corneal swelling, increased eye size (buphthalmos), opacity, and optic nerve damage due to elevated IOP.
  • High consanguinity rates correlate with PCG prevalence in certain communities.

Conclusions:

  • Early screening and diagnosis of PCG in children are crucial for preventing irreversible vision loss.
  • Effective treatments like trabeculectomy and gonioscopy exist, but access and resources are critical, especially in developing countries.
  • Further research into the genetic factors and environmental influences of PCG is necessary to improve outcomes and reduce global blindness.