Regulation and function of V-ATPases in physiology and disease
Michael P Collins1, Michael Forgac2
1Cell, Molecular and Developmental Biology, Tufts University Graduate School of Biomedical Sciences, United States of America.
Biochimica Et Biophysica Acta. Biomembranes
|May 19, 2020
Summary
Vacuolar H+-ATPases (V-ATPases) are vital proton pumps involved in cellular processes and diseases. This review details recent V-ATPase research, focusing on regulation, cancer roles, and therapeutic potential.
Area of Science:
- Cell Biology
- Biochemistry
- Molecular Biology
Background:
- Vacuolar H+-ATPases (V-ATPases) are crucial ATP-dependent proton pumps in eukaryotic membranes.
- They regulate intracellular acidification for processes like membrane traffic, protein degradation, and autophagy.
- Plasma membrane V-ATPases are vital in specialized cells for bone resorption, sperm maturation, and urinary acidification.
Purpose of the Study:
- To review recent advancements in V-ATPase structure, mechanism, function, and regulation.
- To emphasize signaling pathways controlling V-ATPase assembly in mammalian cells.
- To discuss the role of V-ATPases in cancer and other human pathologies, including therapeutic prospects.
Main Methods:
- Literature review of recent scientific publications on V-ATPases.
- Analysis of V-ATPase structure, function, and regulatory mechanisms.
- Examination of V-ATPase involvement in physiological and pathological processes.
Main Results:
- V-ATPases are implicated in diverse cellular functions and various human diseases.
- Recent studies have elucidated V-ATPase structure, mechanism, and regulatory pathways.
- V-ATPases play significant roles in cancer progression and invasiveness.
Conclusions:
- V-ATPases are essential for cellular homeostasis and implicated in numerous pathologies.
- Understanding V-ATPase regulation and function offers potential therapeutic targets.
- Further research into V-ATPases holds promise for treating diseases like cancer and osteopetrosis.
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