Related Experiment Video
Updated: Dec 21, 2025

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
Recent advances, challenges and perspectives in enantioselective release
Lujie Song1, Ming Pan2, Ran Zhao2
1State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China; College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China; State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China.
This review explores enantioselective release of chiral drugs, focusing on chiral materials. It addresses challenges and emerging issues like chiral inversion and environmental pollutants for safer drug development.
Area of Science:
- Pharmaceutical Chemistry
- Materials Science
- Environmental Science
Background:
- Chiral drugs, existing as enantiomers with different effects, are often racemic.
- Enantioselective release offers alternative uses for chiral drugs.
- Limited reviews exist on enantioselective release, highlighting the need for updated research.
Purpose of the Study:
- To review recent advancements in enantioselective release.
- To emphasize the construction of chiral releasing materials.
- To summarize challenges and emerging issues in chiral drug release.
Main Methods:
- Literature review focusing on enantioselective release systems.
- Analysis of chiral carrier-chiral guest and chiral carrier-achiral guest systems.
- Discussion of chiral inversion and environmental impact.
Main Results:
- Progress in constructing chiral releasing materials.
- Identification of challenges in achieving enantioselective release.
- Summary of issues including chiral inversion and environmental contamination.
Conclusions:
- Enantioselective release is crucial for optimizing chiral drug efficacy and safety.
- Further research on chiral materials and release mechanisms is needed.
- Addressing environmental concerns related to chiral compounds is essential.
Related Concept Videos
Stereochemical Effects of Enolization
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
Regioselective Formation of Enolates
Sharpless Epoxidation
Reactivity of Enols
Prochirality

