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Updated: Jul 13, 2026
Facile Preparation of 4-Substituted Quinazoline Derivatives
Published on: February 15, 2016
A One-Dimensional Thorium-Containing Arsenotungstate for the Synthesis of 2,3-Dihydroquinazolinones
Jun Wu1, Xuejiao Chen1, Mingze Zhao1
1National Key Laboratory of Uranium Resources Exploration-Mining and Nuclear Remote Sensing, Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation, School of Chemistry and Materials Science, East China University of Technology, Nanchang330013, China.
Abstract:
A novel one-dimensional chain thorium-containing arsenotungstate, H12[(Th2W3O10)(AsW9O33)2(H2O)6]·14H2O (Th2As2W21), has been successfully synthesized. Th2As2W21 consists of a {Th2W3} unit that connects two {AsW9} units to form a dimer. Adjacent dimers are linked through two Th-O-W bonds, resulting in an interesting wavy one-dimensional chain. Notably, the incorporation of Th4+ endows Th2As2W21 with remarkable Lewis acidity, enabling it to function as an efficient heterogeneous catalyst for the condensation-cyclization reaction between 2-aminobenzamide and aldehydes to afford 2,3-dihydroquinazolinones. Under environmentally friendly and mild conditions, a series of 2,3-dihydroquinazolinones was obtained in excellent yields (up to 98%). This study not only enriches the structural diversity of thorium-containing polyoxometalates but also provides a promising heterogeneous catalyst for the sustainable synthesis of N-heterocycles.
